The G-quadruplex-forming aptamer AS1411 potently inhibits HIV-1 attachment to the host cell

AS1411 is a G-rich aptamer that forms a stable G-quadruplex structure and displays antineoplastic properties both in vitro and in vivo. This oligonucleotide has undergone phase 2 clinical trials. The major molecular target of AS1411 is nucleolin (NCL), a multifunctional nucleolar protein also presen...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Antimicrob Agents
Prif Awduron: Perrone, Rosalba, Butovskaya, Elena, Lago, Sara, Garzino-Demo, Alfredo, Pannecouque, Christophe, Palù, Giorgio, Richter, Sara N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Elsevier Science Publishers 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4840014/
https://ncbi.nlm.nih.gov/pubmed/27032748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijantimicag.2016.01.016
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