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The G-quadruplex-forming aptamer AS1411 potently inhibits HIV-1 attachment to the host cell
AS1411 is a G-rich aptamer that forms a stable G-quadruplex structure and displays antineoplastic properties both in vitro and in vivo. This oligonucleotide has undergone phase 2 clinical trials. The major molecular target of AS1411 is nucleolin (NCL), a multifunctional nucleolar protein also presen...
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| Publicado no: | Int J Antimicrob Agents |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Science Publishers
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4840014/ https://ncbi.nlm.nih.gov/pubmed/27032748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijantimicag.2016.01.016 |
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