Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes

[Image: see text] We have previously reported that stabilization of the G-quadruplex structures in the HIV-1 long terminal repeat (LTR) promoter suppresses viral transcription. Here we sought to develop new G-quadruplex ligands to be exploited as antiviral compounds by enhancing binding toward the v...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Perrone, Rosalba, Doria, Filippo, Butovskaya, Elena, Frasson, Ilaria, Botti, Silvia, Scalabrin, Matteo, Lago, Sara, Grande, Vincenzo, Nadai, Matteo, Freccero, Mauro, Richter, Sara N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4690987/
https://ncbi.nlm.nih.gov/pubmed/26599611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b01283
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