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Lactic acid polarizes macrophages to a tumor-promoting state

Tumor-associated macrophages have been associated with a poor prognosis in most types of tumors. However, tumor-derived signals that activate macrophages have not been well defined. We review our recent finding that tumor-derived lactic acid is necessary and sufficient to polarize tumor-associated m...

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Pubblicato in:Oncoimmunology
Autore principale: Colegio, Oscar R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839384/
https://ncbi.nlm.nih.gov/pubmed/27141329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1014774
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