Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid

Lactate dehydrogenase A (LDHA) is an important enzyme responsible for cancer growth and energy metabolism in various cancers via the aerobic glycolytic pathway. Here, we report that machilin A (MA), which acts as a competitive inhibitor by blocking the nicotinamide adenine dinucleotide (NAD) binding...

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Détails bibliographiques
Publié dans:Cancers (Basel)
Auteurs principaux: Chung, Tae-Wook, Kim, Eun-Yeong, Han, Chang Woo, Park, So Young, Jeong, Mi Suk, Yoon, Dahye, Choi, Hee-Jung, Jin, Ling, Park, Mi-Ju, Kwon, Yun Ju, Lee, Hanna, Kim, Keuk-Jun, Park, Kang Hyun, Kim, Suhkmann, Jang, Se Bok, Ha, Ki-Tae
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6678097/
https://ncbi.nlm.nih.gov/pubmed/31324019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11070963
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