PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2

Adaptive β-cell replication occurs in response to increased metabolic demand during insulin resistance. The intracellular mediators of this compensatory response are poorly defined and their identification could provide significant targets for β-cell regeneration therapies. Here we show that glucose...

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Detalles Bibliográficos
Publicado en:Diabetes
Main Authors: Lakshmipathi, Jayalakshmi, Alvarez-Perez, Juan Carlos, Rosselot, Carolina, Casinelli, Gabriella P., Stamateris, Rachel E., Rausell-Palamos, Francisco, O’Donnell, Christopher P., Vasavada, Rupangi C., Scott, Donald K., Alonso, Laura C., Garcia-Ocaña, Adolfo
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2016
Assuntos:
Islet Studies
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4839210/
https://ncbi.nlm.nih.gov/pubmed/26868297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db15-1398
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