Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones

Polypeptide aggregation into amyloid is linked with several debilitating human diseases. Despite the inherent risk of aggregation-induced cytotoxicity, bacteria control the export of amyloid-prone subunits and assemble adhesive amyloid fibres during biofilm formation. An Escherichia protein, CsgC po...

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Published in:Sci Rep
Main Authors: Taylor, Jonathan D., Hawthorne, William J., Lo, Joanne, Dear, Alexander, Jain, Neha, Meisl, Georg, Andreasen, Maria, Fletcher, Catherine, Koch, Marion, Darvill, Nicholas, Scull, Nicola, Escalera-Maurer, Andrés, Sefer, Lea, Wenman, Rosemary, Lambert, Sebastian, Jean, Jisoo, Xu, Yingqi, Turner, Benjamin, Kazarian, Sergei G., Chapman, Matthew R., Bubeck, Doryen, de Simone, Alfonso, Knowles, Tuomas P. J., Matthews, Steve J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838910/
https://ncbi.nlm.nih.gov/pubmed/27098162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep24656
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