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Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter

Despite the well-established role of the human serotonin transporter (hSERT) in the treatment of depression, the molecular details of antidepressant drug binding are still not fully understood. Here we utilize amber codon suppression in a membrane-bound transporter protein to encode photocrosslinkin...

詳細記述

保存先:
書誌詳細
出版年:Nat Commun
主要な著者: Rannversson, Hafsteinn, Andersen, Jacob, Sørensen, Lena, Bang-Andersen, Benny, Park, Minyoung, Huber, Thomas, Sakmar, Thomas P., Strømgaard, Kristian
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838859/
https://ncbi.nlm.nih.gov/pubmed/27089947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11261
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