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Mapping the Ligand-binding Site on a GPCR Using Genetically-encoded Photocrosslinkers
We developed a general cell-based photocrosslinking approach to investigate the binding interfaces necessary for the formation of G protein-coupled receptor (GPCR) signaling complexes. The two photoactivatable unnatural amino acids p-benzoyl-L-phenylalanine and p-azido-L-phenylalanine were incorpora...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3099303/ https://ncbi.nlm.nih.gov/pubmed/21417335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200214r |
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