Mapping Substance P Binding Sites on the Neurokinin-1 Receptor Using Genetic Incorporation of a Photoreactive Amino Acid

Substance P (SP) is a neuropeptide that mediates numerous physiological responses, including transmission of pain and inflammation through the neurokinin-1 (NK1) receptor, a G protein-coupled receptor. Previous mutagenesis studies and photoaffinity labeling using ligand analogues suggested that the...

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Detalhes bibliográficos
Main Authors: Valentin-Hansen, Louise, Park, Minyoung, Huber, Thomas, Grunbeck, Amy, Naganathan, Saranga, Schwartz, Thue W., Sakmar, Thomas P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140293/
https://ncbi.nlm.nih.gov/pubmed/24831006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527085
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