Quantitative sampling of conformational heterogeneity of a DNA hairpin using molecular dynamics simulations and ultrafast fluorescence spectroscopy

Molecular dynamics (MD) simulations and time resolved fluorescence (TRF) spectroscopy were combined to quantitatively describe the conformational landscape of the DNA primary binding sequence (PBS) of the HIV-1 genome, a short hairpin targeted by retroviral nucleocapsid proteins implicated in the vi...

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Библиографические подробности
Опубликовано в: :Nucleic Acids Res
Главные авторы: Voltz, Karine, Léonard, Jérémie, Touceda, Patricia Tourón, Conyard, Jamie, Chaker, Ziyad, Dejaegere, Annick, Godet, Julien, Mély, Yves, Haacke, Stefan, Stote, Roland H.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2016
Предметы:
Structural Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838372/
https://ncbi.nlm.nih.gov/pubmed/26896800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw077
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