Quantitative sampling of conformational heterogeneity of a DNA hairpin using molecular dynamics simulations and ultrafast fluorescence spectroscopy

Molecular dynamics (MD) simulations and time resolved fluorescence (TRF) spectroscopy were combined to quantitatively describe the conformational landscape of the DNA primary binding sequence (PBS) of the HIV-1 genome, a short hairpin targeted by retroviral nucleocapsid proteins implicated in the vi...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Voltz, Karine, Léonard, Jérémie, Touceda, Patricia Tourón, Conyard, Jamie, Chaker, Ziyad, Dejaegere, Annick, Godet, Julien, Mély, Yves, Haacke, Stefan, Stote, Roland H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
Structural Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838372/
https://ncbi.nlm.nih.gov/pubmed/26896800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw077
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