Quantitative sampling of conformational heterogeneity of a DNA hairpin using molecular dynamics simulations and ultrafast fluorescence spectroscopy

Molecular dynamics (MD) simulations and time resolved fluorescence (TRF) spectroscopy were combined to quantitatively describe the conformational landscape of the DNA primary binding sequence (PBS) of the HIV-1 genome, a short hairpin targeted by retroviral nucleocapsid proteins implicated in the vi...

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Spremljeno u:
Bibliografski detalji
Izdano u:Nucleic Acids Res
Glavni autori: Voltz, Karine, Léonard, Jérémie, Touceda, Patricia Tourón, Conyard, Jamie, Chaker, Ziyad, Dejaegere, Annick, Godet, Julien, Mély, Yves, Haacke, Stefan, Stote, Roland H.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Structural Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4838372/
https://ncbi.nlm.nih.gov/pubmed/26896800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw077
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