Vertebrate Fidgetin Restrains Axonal Growth by Severing Labile Domains of Microtubules

Individual microtubules (MTs) in the axon consist of a stable domain that is highly acetylated and a labile domain that is not. Traditional MT-severing proteins preferentially cut the MT in the stable domain. In Drosophila, fidgetin behaves in this fashion, with targeted knockdown resulting in neuro...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Leo, Lanfranco, Yu, Wenqian, D’Rozario, Mitchell, Waddell, Edward A., Marenda, Daniel R., Baird, Michelle A., Davidson, Michael W., Zhou, Bin, Wu, Bingro, Baker, Lisa, Sharp, David J., Baas, Peter W.
Format: Artigo
Langue:Inglês
Publié: 2015
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4837332/
https://ncbi.nlm.nih.gov/pubmed/26344772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.017
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