लोड हो रहा है...
Pathogenic Mutation of Spastin Has Gain-of-Function Effects on Microtubule Dynamics
Mutations to the SPG4 gene encoding the microtubule-severing protein spastin are the most common cause of hereditary spastic paraplegia. Haploinsufficiency, the prevalent model for the disease, cannot readily explain many of its key aspects, such as its adult onset or its specificity for the cortico...
में बचाया:
| मुख्य लेखकों: | , , , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Society for Neuroscience
2014
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3905148/ https://ncbi.nlm.nih.gov/pubmed/24478365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3309-13.2014 |
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