Pathogenic Mutation of Spastin Has Gain-of-Function Effects on Microtubule Dynamics

Mutations to the SPG4 gene encoding the microtubule-severing protein spastin are the most common cause of hereditary spastic paraplegia. Haploinsufficiency, the prevalent model for the disease, cannot readily explain many of its key aspects, such as its adult onset or its specificity for the cortico...

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Bibliographic Details
Main Authors: Solowska, Joanna M., D'Rozario, Mitchell, Jean, Daphney C., Davidson, Michael W., Marenda, Daniel R., Baas, Peter W.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3905148/
https://ncbi.nlm.nih.gov/pubmed/24478365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3309-13.2014
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