Quantitative and Functional Analyses of Spastin in the Nervous System: Implications for Hereditary Spastic Paraplegia

Spastin and P60-katanin are two distinct microtubule-severing proteins. Autosomal dominant mutations in the SPG4 locus corresponding to spastin are the most common cause of hereditary spastic paraplegia (HSP), a neurodegenerative disease that afflicts the adult corticospinal tracts. Here we sought t...

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Detalhes bibliográficos
Main Authors: Solowska, Joanna M., Morfini, Gerardo, Falnikar, Aditi, Himes, B. Timothy, Brady, Scott T., Huang, Dongyang, Baas, Peter W.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2008
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2693295/
https://ncbi.nlm.nih.gov/pubmed/18305248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3159-07.2008
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