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Cell-Penetrating Pepducin Therapy Targeting PAR1 in Subjects With Coronary Artery Disease

OBJECTIVE: Pepducins are membrane-tethered, cell-penetrating lipopeptides that target the cytoplasmic surface of their cognate receptor. Here, we report the first human use of a protease-activated receptor-1–based pepducin, which is intended as an antiplatelet agent to prevent ischemic complications...

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Detalles Bibliográficos
Publicado en:Arterioscler Thromb Vasc Biol
Autores principales: Gurbel, Paul A., Bliden, Kevin P., Turner, Susan E., Tantry, Udaya S., Gesheff, Martin G., Barr, Travis P., Covic, Lidija, Kuliopulos, Athan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836853/
https://ncbi.nlm.nih.gov/pubmed/26681756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306777
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