PAR2 Pepducin-Based Suppression of Inflammation and Itch in Atopic Dermatitis Models

PAR2 has been proposed to contribute to lesion formation and intense itch in atopic dermatitis. Here, we tested the ability of a cell-penetrating pepducin, PZ-235, to mitigate the potentially deleterious effects of PAR2 in models of atopic dermatitis. PZ-235 significantly inhibited PAR2-mediated exp...

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Publicado en:J Invest Dermatol
Autores principales: Barr, Travis P., Garzia, Chris, Guha, Srijoy, Fletcher, Elizabeth K., Nguyen, Nga, Wieschhaus, Adam J., Ferrer, Lluis, Covic, Lidija, Kuliopulos, Athan
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6830517/
https://ncbi.nlm.nih.gov/pubmed/30287285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jid.2018.08.019
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