Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis

The potassium channel Kv1.3 plays roles in immunity, neuronal development and sensory discrimination. Regulation of Kv1.3 by kinase signaling has been studied. In this context, EGF binds to specific receptors (EGFR) and triggers tyrosine kinase-dependent signaling, which down-regulates Kv1.3 current...

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Опубликовано в: :Cell Mol Life Sci
Главные авторы: Martínez-Mármol, Ramón, Comes, Núria, Styrczewska, Katarzyna, Pérez-Verdaguer, Mireia, Vicente, Rubén, Pujadas, Lluís, Soriano, Eduardo, Sorkin, Alexander, Felipe, Antonio
Формат: Artigo
Язык:Inglês
Опубликовано: Springer International Publishing 2015
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836834/
https://ncbi.nlm.nih.gov/pubmed/26542799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-015-2082-0
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