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Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing
Pre-mRNA splicing must occur with high fidelity and efficiency for proper gene expression. The spliceosome uses DExD/H box helicases to promote on-pathway interactions while simultaneously minimizing errors. Prp8 and Snu114, an EF2-like GTPase, regulate the activity of the Brr2 helicase, promoting R...
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| 出版年: | RNA |
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| 主要な著者: | , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4836653/ https://ncbi.nlm.nih.gov/pubmed/26968627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.055459.115 |
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