Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants

Prp8 is a critical pre-mRNA splicing factor. Prp8 is proposed to help form and stabilize the spliceosome catalytic core and to be an important regulator of spliceosome activation. Mutations in human Prp8 (hPrp8) cause a severe form of the genetic disorder retinitis pigmentosa, RP13. Understanding th...

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Detalhes bibliográficos
Main Authors: Zhang, Lingdi, Shen, Jingping, Guarnieri, Michael T., Heroux, Annie, Yang, Kui, Zhao, Rui
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2007
Assuntos:
Accelerated Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2206663/
https://ncbi.nlm.nih.gov/pubmed/17473007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.072872007
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