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Crystal structure of the C-terminal domain of splicing factor Prp8 carrying retinitis pigmentosa mutants
Prp8 is a critical pre-mRNA splicing factor. Prp8 is proposed to help form and stabilize the spliceosome catalytic core and to be an important regulator of spliceosome activation. Mutations in human Prp8 (hPrp8) cause a severe form of the genetic disorder retinitis pigmentosa, RP13. Understanding th...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2206663/ https://ncbi.nlm.nih.gov/pubmed/17473007 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.072872007 |
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