Prp8 impacts cryptic but not alternative splicing frequency

Pre-mRNA splicing must occur with extremely high fidelity. Spliceosomes assemble onto pre-mRNA guided by specific sequences (5′ splice site, 3′ splice site, and branchpoint). When splice sites are mutated, as in many hereditary diseases, the spliceosome can aberrantly select nearby pseudo- or “crypt...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Mayerle, Megan, Yitiz, Samira, Soulette, Cameron, Rogel, Lucero E., Ramirez, Andrea, Ragle, J. Matthew, Katzman, Sol, Guthrie, Christine, Zahler, Alan M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2019
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369775/
https://ncbi.nlm.nih.gov/pubmed/30674666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1819020116
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