Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency

Pre-mRNA splicing is an essential step of eukaryotic gene expression that requires both high efficiency and high fidelity. Prp8 has long been considered the “master regulator” of the spliceosome, the molecular machine that executes pre-mRNA splicing. Cross-linking and structural studies place the RN...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Mayerle, Megan, Raghavan, Madhura, Ledoux, Sarah, Price, Argenta, Stepankiw, Nicholas, Hadjivassiliou, Haralambos, Moehle, Erica A., Mendoza, Senén D., Pleiss, Jeffrey A., Guthrie, Christine, Abelson, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2017
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422793/
https://ncbi.nlm.nih.gov/pubmed/28416677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701462114
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