Structural toggle in the RNaseH domain of Prp8 helps balance splicing fidelity and catalytic efficiency

Pre-mRNA splicing is an essential step of eukaryotic gene expression that requires both high efficiency and high fidelity. Prp8 has long been considered the “master regulator” of the spliceosome, the molecular machine that executes pre-mRNA splicing. Cross-linking and structural studies place the RN...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Mayerle, Megan, Raghavan, Madhura, Ledoux, Sarah, Price, Argenta, Stepankiw, Nicholas, Hadjivassiliou, Haralambos, Moehle, Erica A., Mendoza, Senén D., Pleiss, Jeffrey A., Guthrie, Christine, Abelson, John
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5422793/
https://ncbi.nlm.nih.gov/pubmed/28416677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1701462114
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