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Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing

Pre-mRNA splicing must occur with high fidelity and efficiency for proper gene expression. The spliceosome uses DExD/H box helicases to promote on-pathway interactions while simultaneously minimizing errors. Prp8 and Snu114, an EF2-like GTPase, regulate the activity of the Brr2 helicase, promoting R...

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Bibliografiske detaljer
Udgivet i:RNA
Main Authors: Mayerle, Megan, Guthrie, Christine
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836653/
https://ncbi.nlm.nih.gov/pubmed/26968627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.055459.115
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