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Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing
Pre-mRNA splicing must occur with high fidelity and efficiency for proper gene expression. The spliceosome uses DExD/H box helicases to promote on-pathway interactions while simultaneously minimizing errors. Prp8 and Snu114, an EF2-like GTPase, regulate the activity of the Brr2 helicase, promoting R...
Guardat en:
| Publicat a: | RNA |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4836653/ https://ncbi.nlm.nih.gov/pubmed/26968627 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.055459.115 |
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