Differential in vivo tumorigenicity of diverse KRAS mutations in vertebrate pancreas: A comprehensive survey

Somatic activation of the KRAS proto-oncogene is evident in almost all pancreatic cancers, and appears to represent an initiating event. These mutations occur primarily at codon 12 and less frequently at codons 13 and 61. While some studies have suggested that different KRAS mutations may have varia...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Park, Joon Tae, Johnson, Nicole, Liu, Shu, Levesque, Mathieu, Wang, Yue J., Ho, Hao, Huso, David, Maitra, Anirban, Parsons, Michael J., Prescott, Jason D., Leach, Steven D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836617/
https://ncbi.nlm.nih.gov/pubmed/25065594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.223
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