Small-molecule CFTR activators increase tear secretion and prevent experimental dry eye disease

Dry eye disorders, including Sjögren’s syndrome, constitute a common problem in the aging population, with limited effective therapeutic options available. The cAMP-activated Cl(−) channel cystic fibrosis transmembrane conductance regulator (CFTR) is a major prosecretory channel at the ocular surfac...

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Dades bibliogràfiques
Publicat a:FASEB J
Autors principals: Flores, Alyssa M., Casey, Scott D., Felix, Christian M., Phuan, Puay W., Verkman, A. S., Levin, Marc H.
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2016
Matèries:
Research Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836376/
https://ncbi.nlm.nih.gov/pubmed/26842854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500180
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