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Progesterone receptor chaperone complex-based highthroughput screening assay: identification of capsaicin as inhibitor of Hsp90 machine

Hsp90 and its co-chaperones are known to be important for cancer cell survival. The N-terminal inhibitors of Hsp90 that are in ongoing clinical trials as anti-tumor agents have unfortunately shown disappointing efficacies in the clinic. Thus, novel inhibitors of the Hsp90 machine with different mech...

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Vydáno v:J Biomol Screen
Hlavní autoři: Patwardhan, Chaitanya A., Alfa, Eyad, Lu, Su, Chadli, Ahmed
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836055/
https://ncbi.nlm.nih.gov/pubmed/25184514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1087057114549147
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