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The COP9 signalosome coerces autophagy and the ubiquitin-proteasome system to police the heart
We demonstrated for the first time that the COP9 signalosome (COPS) controls the degradation of a surrogate and a bona fide misfolded protein in the cytosol of cardiomyocytes likely via supporting ubiquitination by CUL/cullin-RING ligases, and that Cops8 hypomorphism exacerbates cardiac proteinopath...
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| 發表在: | Autophagy |
|---|---|
| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Taylor & Francis
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4836033/ https://ncbi.nlm.nih.gov/pubmed/26760900 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2015.1136773 |
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