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Dosage-dependent role of Rac1 in podocyte injury

Activation of small GTPase Rac1 in podocytes is associated with rodent models of kidney injury and familial nephrotic syndrome. Induced Rac1 activation in podocytes in transgenic mice results in rapid transient proteinuria and foot process effacement, but not glomerular sclerosis. Thus it remains an...

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Detalles Bibliográficos
Publicado en:Am J Physiol Renal Physiol
Main Authors: Wan, Xiaoyang, Lee, Mi-Sun, Zhou, Weibin
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835924/
https://ncbi.nlm.nih.gov/pubmed/26792065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00381.2015
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