Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia

BACKGROUND: Hyperammonemia induces neuroinflammation and increases GABAergic tone in the cerebellum which contributes to cognitive and motor impairment in hepatic encephalopathy (HE). The link between neuroinflammation and GABAergic tone remains unknown. New treatments reducing neuroinflammation and...

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Veröffentlicht in:J Neuroinflammation
Hauptverfasser: Hernandez-Rabaza, Vicente, Cabrera-Pastor, Andrea, Taoro-Gonzalez, Lucas, Gonzalez-Usano, Alba, Agusti, Ana, Balzano, Tiziano, Llansola, Marta, Felipo, Vicente
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2016
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4835883/
https://ncbi.nlm.nih.gov/pubmed/27090509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0549-z
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