Pharmacokinetics, pharmacodynamics and adverse event profile of GSK2256294, a novel soluble epoxide hydrolase inhibitor

AIMS: Endothelial‐derived epoxyeicosatrienoic acids may regulate vascular tone and are metabolized by soluble epoxide hydrolase enzymes (sEH). GSK2256294 is a potent and selective sEH inhibitor that was tested in two phase I studies. METHODS: Single escalating doses of GSK2256294 2–20 mg or placebo...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Lazaar, Aili L., Yang, Lucy, Boardley, Rebecca L., Goyal, Navin S., Robertson, Jonathan, Baldwin, Sandra J., Newby, David E., Wilkinson, Ian B., Tal‐Singer, Ruth, Mayer, Ruth J., Cheriyan, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Pharmacokinetic Dynamic Relationships
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834590/
https://ncbi.nlm.nih.gov/pubmed/26620151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12855
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados