Sex- and Isoform-Specific Mechanism of Neuroprotection by Transgenic Expression of P450 Epoxygenase in Vascular Endothelium

OBJECTIVE: Cytochrome P450 epoxygenases (CYP) metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs), which exhibit vasodilatory, anti-inflammatory and neuroprotective actions in experimental cerebral ischemia. We evaluated the effect of endothelial-specific CYP overexpression on cerebral b...

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Publicado no:Exp Neurol
Main Authors: Jia, Jia, Davis, Catherine M, Zhang, Wenri, Edin, Matthew L., Jouihan, Sari, Jia, Taiping, Bradbury, J. Alyce, Graves, Joan P., DeGraff, Laura M., Lee, Craig R., Ronnekleiv, Oline, Wang, Ruikang, Xu, Yun, Zeldin, Darryl C., Alkayed, Nabil J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834246/
https://ncbi.nlm.nih.gov/pubmed/26902473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2016.02.016
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