Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice

Renal cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) regulate sodium transport and blood pressure. Although endothelial CYP-derived EETs are potent vasodilators, their contribution to the regulation of blood pressure remains unclear. Consequently, we developed transgenic mice with en...

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Detalhes bibliográficos
Main Authors: Lee, Craig R., Imig, John D., Edin, Matthew L., Foley, Julie, DeGraff, Laura M., Bradbury, J. Alyce, Graves, Joan P., Lih, Fred B., Clark, James, Myers, Page, Perrow, A. Ligon, Lepp, Adrienne N., Kannon, M. Alison, Ronnekleiv, Oline K., Alkayed, Nabil J., Falck, John R., Tomer, Kenneth B., Zeldin, Darryl C.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2010
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2996903/
https://ncbi.nlm.nih.gov/pubmed/20495177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-160119
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