Optimization of 2-Phenylcyclopropylmethylamines as Selective Serotonin 2C Receptor Agonists and Their Evaluation as Potential Antipsychotic Agents

The discovery of a new series of compounds that are potent, selective 5-HT(2C) receptor agonists is described herein as we continue our efforts to optimize the 2-phenylcyclopropylmethylamine scaffold. Modifications focused on the alkoxyl substituent present on the aromatic ring led to the identifica...

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Vydáno v:J Med Chem
Hlavní autoři: Cheng, Jianjun, Giguère, Patrick M., Onajole, Oluseye K., Lv, Wei, Gaisin, Arsen, Gunosewoyo, Hendra, Schmerberg, Claire M., Pogorelov, Vladimir M., Rodriguiz, Ramona M., Vistoli, Giulio, Wetsel, William C., Roth, Bryan L., Kozikowski, Alan P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4834193/
https://ncbi.nlm.nih.gov/pubmed/25633969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5019274
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