RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

RAS signalling through phosphoinositide 3-kinase (PI3-Kinase) has been shown to have an essential role in tumour initiation and maintenance. RAS also regulates cell motility and tumour invasiveness, but the role of direct RAS binding to PI3-Kinase in this remains uncertain. Here, we provide evidence...

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Udgivet i:Nat Commun
Main Authors: Castellano, Esther, Molina-Arcas, Miriam, Krygowska, Agata Adelajda, East, Philip, Warne, Patricia, Nicol, Alastair, Downward, Julian
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833863/
https://ncbi.nlm.nih.gov/pubmed/27071537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11245
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