Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly

The human molecular chaperones heat shock protein 70 (Hsp70) and heat shock cognate protein 70 (Hsc70) bind to the hepatitis C viral nonstructural protein 5A (NS5A) and regulate its activity. Specifically, Hsp70 is involved in NS5A-augmented internal ribosomal entry site (IRES)-mediated translation...

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Udgivet i:Int J Antimicrob Agents
Main Authors: Khachatoorian, Ronik, Riahi, Rana, Ganapathy, Ekambaram, Shao, Hao, Wheatley, Nicole M., Sundberg, Christopher, Jung, Chun-Ling, Ruchala, Piotr, Dasgupta, Asim, Arumugaswami, Vaithilingaraja, Gestwicki, Jason E., French, Samuel W.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833571/
https://ncbi.nlm.nih.gov/pubmed/27013001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijantimicag.2016.01.012
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