Structural characterization of the HSP70 interaction domain of the hepatitis C viral protein NS5A

We previously identified the NS5A/HSP70 binding site to be a hairpin moiety at C-terminus of NS5A domain I and showed a corresponding cyclized polyarginine-tagged synthetic peptide (HCV4) significantly blocks virus production. Here, sequence comparison confirmed five residues to be conserved. Based...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Virology
Autori principali: Khachatoorian, Ronik, Ruchala, Piotr, Waring, Alan, Jung, Chun-Ling, Ganapathy, Ekambaram, Wheatley, Nicole, Sundberg, Christopher, Arumugaswami, Vaithilingaraja, Dasgupta, Asim, French, Samuel W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284078/
https://ncbi.nlm.nih.gov/pubmed/25462345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.10.011
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi