Structural characterization of the HSP70 interaction domain of the hepatitis C viral protein NS5A

We previously identified the NS5A/HSP70 binding site to be a hairpin moiety at C-terminus of NS5A domain I and showed a corresponding cyclized polyarginine-tagged synthetic peptide (HCV4) significantly blocks virus production. Here, sequence comparison confirmed five residues to be conserved. Based...

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Publicado no:Virology
Main Authors: Khachatoorian, Ronik, Ruchala, Piotr, Waring, Alan, Jung, Chun-Ling, Ganapathy, Ekambaram, Wheatley, Nicole, Sundberg, Christopher, Arumugaswami, Vaithilingaraja, Dasgupta, Asim, French, Samuel W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4284078/
https://ncbi.nlm.nih.gov/pubmed/25462345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.10.011
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