The NS5A-binding heat shock proteins HSC70 and HSP70 play distinct roles in the hepatitis C viral life cycle

We previously identified HSP70 and HSC70 in complex with NS5A in a proteomic screen. Here, coimmunoprecipitation studies confirmed NS5A/HSC70 complex formation during infection, and immunofluorescence studies showed NS5A and HSC70 to colocalize. Unlike HSP70, HSC70 knockdown did not decrease viral p...

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Detalhes bibliográficos
Main Authors: Khachatoorian, Ronik, Ganapathy, Ekambaram, Ahmadieh, Yasaman, Wheatley, Nicole, Sundberg, Christopher, Jung, Chun-Ling, Arumugaswami, Vaithilingaraja, Raychaudhuri, Santanu, Dasgupta, Asim, French, Samuel W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011396/
https://ncbi.nlm.nih.gov/pubmed/24725938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2014.02.016
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