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Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth

Mammalian microRNA expression is dysregulated in human cancer. However, the functional relevance of many microRNAs in the context of tumor biology remains unclear. Using CRISPR-Cas9 technology, we performed a global loss-of-function screen to simultaneously test the functions of individual microRNAs...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Wallace, Jared, Hu, Ruozhen, Mosbruger, Timothy L., Dahlem, Timothy J., Stephens, W. Zac, Rao, Dinesh S., Round, June L., O’Connell, Ryan M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2016
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833428/
https://ncbi.nlm.nih.gov/pubmed/27081855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153689
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