Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth

Mammalian microRNA expression is dysregulated in human cancer. However, the functional relevance of many microRNAs in the context of tumor biology remains unclear. Using CRISPR-Cas9 technology, we performed a global loss-of-function screen to simultaneously test the functions of individual microRNAs...

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Veröffentlicht in:PLoS One
Hauptverfasser: Wallace, Jared, Hu, Ruozhen, Mosbruger, Timothy L., Dahlem, Timothy J., Stephens, W. Zac, Rao, Dinesh S., Round, June L., O’Connell, Ryan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833428/
https://ncbi.nlm.nih.gov/pubmed/27081855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153689
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