Genome-Wide CRISPR-Cas9 Screen Identifies MicroRNAs That Regulate Myeloid Leukemia Cell Growth

Mammalian microRNA expression is dysregulated in human cancer. However, the functional relevance of many microRNAs in the context of tumor biology remains unclear. Using CRISPR-Cas9 technology, we performed a global loss-of-function screen to simultaneously test the functions of individual microRNAs...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS One
Prif Awduron: Wallace, Jared, Hu, Ruozhen, Mosbruger, Timothy L., Dahlem, Timothy J., Stephens, W. Zac, Rao, Dinesh S., Round, June L., O’Connell, Ryan M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833428/
https://ncbi.nlm.nih.gov/pubmed/27081855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0153689
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