CD4 Receptor is a Key Determinant of Divergent HIV-1 Sensing by Plasmacytoid Dendritic Cells

Plasmacytoid dendritic cells (pDC) are innate immune cells that sense viral nucleic acids through endosomal Toll-like receptor (TLR) 7/9 to produce type I interferon (IFN) and to differentiate into potent antigen presenting cells (APC). Engagement of TLR7/9 in early endosomes appears to trigger the...

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Publicado en:PLoS Pathog
Autores principales: O’Brien, Meagan, Manches, Olivier, Wilen, Craig, Gopal, Ramya, Huq, Rumana, Wu, Vernon, Sunseri, Nicole, Bhardwaj, Nina
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833349/
https://ncbi.nlm.nih.gov/pubmed/27082754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005553
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