Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α–producing and partially matured phenotype

Plasmacytoid DCs (pDCs) are innate immune cells that are specialized to produce IFN-α and to activate adaptive immune responses. Although IFN-α inhibits HIV-1 replication in vitro, the production of IFN-α by HIV-activated pDCs in vivo may contribute more to HIV pathogenesis than to protection. We ha...

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Detalhes bibliográficos
Main Authors: O’Brien, Meagan, Manches, Olivier, Sabado, Rachel Lubong, Jimenez Baranda, Sonia, Wang, Yaming, Marie, Isabelle, Rolnitzky, Linda, Markowitz, Martin, Margolis, David M., Levy, David, Bhardwaj, Nina
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3049388/
https://ncbi.nlm.nih.gov/pubmed/21339641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44960
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