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Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X
Females have a greater immunological advantage than men, yet they are more prone to autoimmune disorders. The basis for this sex bias lies in the X chromosome, which contains many immunity-related genes. Female mammals use X chromosome inactivation (XCI) to generate a transcriptionally silent inacti...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4833277/ https://ncbi.nlm.nih.gov/pubmed/27001848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520113113 |
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