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Unusual maintenance of X chromosome inactivation predisposes female lymphocytes for increased expression from the inactive X

Females have a greater immunological advantage than men, yet they are more prone to autoimmune disorders. The basis for this sex bias lies in the X chromosome, which contains many immunity-related genes. Female mammals use X chromosome inactivation (XCI) to generate a transcriptionally silent inacti...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Wang, Jianle, Syrett, Camille M., Kramer, Marianne C., Basu, Arindam, Atchison, Michael L., Anguera, Montserrat C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833277/
https://ncbi.nlm.nih.gov/pubmed/27001848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520113113
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