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Altered X-chromosome inactivation in T cells may promote sex-biased autoimmune diseases
Systemic lupus erythematosus (SLE) is an autoimmune disorder that predominantly affects women and is driven by autoreactive T cell–mediated inflammation. It is known that individuals with multiple X-chromosomes are at increased risk for developing SLE; however, the mechanisms underlying this genetic...
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| Publicado no: | JCI Insight |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6483655/ https://ncbi.nlm.nih.gov/pubmed/30944248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.126751 |
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