Predicting allopurinol response in patients with gout

AIMS: The primary aim of this research was to predict the allopurinol maintenance doses required to achieve the target plasma urate of ≤0.36 mmol l(−1). METHODS: A population analysis was conducted in nonmem using oxypurinol and urate plasma concentrations from 133 gout patients. Maintenance dose pr...

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Bibliografiske detaljer
Udgivet i:Br J Clin Pharmacol
Main Authors: Wright, Daniel F. B., Duffull, Stephen B., Merriman, Tony R., Dalbeth, Nicola, Barclay, Murray L., Stamp, Lisa K.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2015
Fag:
PK‐PD Relationships
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833152/
https://ncbi.nlm.nih.gov/pubmed/26451524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12799
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