טוען...
Population pharmacokinetics of nalmefene in healthy subjects and its relation to μ‐opioid receptor occupancy
AIMS: The aims of this study were to develop a population pharmacokinetic (PK) model to describe the PK of nalmefene in healthy subjects and to relate the exposure of nalmefene to the μ‐opioid receptor occupancy by simulations in the target population. METHODS: Data from nine phase I studies (243 su...
שמור ב:
| הוצא לאור ב: | Br J Clin Pharmacol |
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| Main Authors: | , , , , , |
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
John Wiley and Sons Inc.
2016
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4833148/ https://ncbi.nlm.nih.gov/pubmed/26483076 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12805 |
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