Population pharmacokinetics of nalmefene in healthy subjects and its relation to μ‐opioid receptor occupancy

AIMS: The aims of this study were to develop a population pharmacokinetic (PK) model to describe the PK of nalmefene in healthy subjects and to relate the exposure of nalmefene to the μ‐opioid receptor occupancy by simulations in the target population. METHODS: Data from nine phase I studies (243 su...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Kyhl, Lars‐Erik Broksoe, Li, Shen, Faerch, Kirstine Ullitz, Soegaard, Birgitte, Larsen, Frank, Areberg, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
PK‐PD Relationships
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4833148/
https://ncbi.nlm.nih.gov/pubmed/26483076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12805
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