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Rad7 E3 Ubiquitin Ligase Attenuates Polyubiquitylation of Rpn10 and Dsk2 Following DNA Damage in Saccharomyces cerevisiae

During Nucleotide Excision Repair (NER) in the yeast S. cerevisiae, ubiquitylation of Rad4 is carried out by the E3 ubiquitin ligase that includes Rad7-Elc1-Cul3 and is critical to optimal NER. Rad7 E3 activity targets Rad4 for degradation by the proteaseome but, in principle, could also trigger oth...

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Detalhes bibliográficos
Publicado no:Adv Biol Chem
Main Authors: Benoun, Joseph M., Lalimar-Cortez, Danielle, Valencia, Analila, Granda, Adriana, Moore, Destaye M., Kelson, Eric P., Fischhaber, Paula L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832922/
https://ncbi.nlm.nih.gov/pubmed/27092291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4236/abc.2015.57021
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