Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylation

The proteasome degrades proteins modified by polyubiquitylation, so correctly controlled ubiquitylation is crucial to avoid unscheduled proteolysis of essential proteins. The mechanism regulating proteolysis of RNAPII has been controversial since two distinct ubiquitin ligases (E3s), Rsp5 (and its h...

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Detalhes bibliográficos
Main Authors: Harreman, Michelle, Taschner, Michael, Sigurdsson, Stefan, Anindya, Roy, Reid, James, Somesh, Baggavalli, Kong, Stephanie E., Banks, Charles A. S., Conaway, Ronald C., Conaway, Joan W., Svejstrup, Jesper Q.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2778569/
https://ncbi.nlm.nih.gov/pubmed/19920177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907052106
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